Copper has long been associated with the formation of protease-resistant, -sheet enriched scrapie conformation of prion protein PrP Sc , which has been considered the critical step in the neurodegenerative prion diseases known as transmissible spongiform encephalopathies [43, 262]
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Effects of creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin A pilot clinical, histologic, and ultrastructural study