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21 Moreover, insulin resistance in the brain often coexists with impaired insulinlike growth factor 1 (IGF1) signalling, given the extensive molecular overlap between their receptors and downstream pathways

A recent case report of a young woman born with generalized congenital dermal melanocytosis who subsequently developed bilateral nevus of Ota and eruptive blue nevi highlights this association [69]

These medications work by reducing appetite and food intake, leading to initial weight loss

They typically start with history, symptoms, and ruling out more common causes (sleep disorders, thyroid issues, depression/anxiety, overtraining, medication effects)

Many PlexusDx patients find that reduced hunger makes it easier to prioritize whole foods and stay active without constant motivation