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MOTS-c Primary focus: Mitochondrial metabolism Insulin sensitivity Metabolic aging in women MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is encoded in mitochondrial DNA not the nuclear genome and functions as a mitochondrial-derived peptide that communicates metabolic stress signals systemically

Deibert DC, DeFronzo RA

In practical terms: Short-term mild warmth (a few hours): May still be safe, but should be monitored carefully

A 2024 study from Epic Research found that people with hypothyroidism who lost more than 5 pounds while taking GLP-1 medications (including semaglutide) saw TSH (thyroid-stimulating hormone) levels decrease by an average of about 0.55 mU/L

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