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2016 Dec
Clinicians must remain cautious: GLP-1 RAs are not fertility treatments and should be discontinued before conception until safety data are robust
Research findings have shown that the stimulation of i NKT cells by liraglutide is correlated with the triggering of fibroblast growth factor 21 (FGF21) synthesis, which subsequently results in weight loss [163]
9 These clinical findings are consistent with preclinical data that berberine activates AMPK and favorably alters lipid metabolism, but the trial did not directly measure GLP-1 or gut microbiota composition
The next critical step will be controlled clinical trials to confirm whether the observed associations translate into a reproducible, disease-modifying benefit
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