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Proanthocyanidins also decrease histamine release from cells by inhibiting several other enzymes

Rotating injection sites helps minimize cumulative irritation

So the uncomfortable conclusion remains: we do not yet have the kind of human trial evidence that should be driving widespread clinical adoption for injury recovery

However, because of the narrow therapeutic window for acute liver injury and the side effects of NAC, its clinical application has great limitations (Du et al., 2016)

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