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FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

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It also positively affects glycated hemoglobin, fasting plasma glucose, and lipid profiles

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Appetite Regulation: They act on the brains hunger centres to reduce food cravings and "food noise," making it easier to stick to a calorie-controlled diet