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Nonetheless, treatment with rapamycin, a recognized inhibitor of mTOR, induced only a mild extension of lifespan in mice (9% for male and 14% for females) [18]

In the two example cases in the left panel, the predicted thresholds of recovery are very different

Based on this assumption, Ile 12 could be replaced with Leu or Val and retain the same effect

The development of 3D culture models and organ-on-chip platforms brought a degree of complexity to classic in vitro for more physiological models of organs including the BBB

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