In fact, the profound ROS accumulation characteristic of sickle RBCs has been demonstrated to be mainly caused by NADPH oxidase, which is regulated by Rac GTPase [179]
Retatrutide, a triple agonist targeting gastric inhibitory polypeptide (GIP), GLP-1, and glucagon receptors, has achieved highly promising outcomes in its phase 2 trial [22], with weight loss up to 24%
That is almost a 50-fold difference in total weekly intake for what is, fundamentally, the same drug, simply because most of the substance is degraded before they can be absorbed into the blood
Antioxidant enzymes play a crucial role in neutralizing excessive ROS, protecting cells and tissues from oxidative damage, and reducing the onset or progression of NCDs
If that doesn't convince you, perhaps the acute effects of low B12 levels will