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2 GLP-1 binds to glucagon-like peptide-1 receptors (GLP-1R) which are class II G protein-coupled receptors
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Global and mitochondrial PKA assays INS-1 832/3 cells were seeded onto 35-mm glass-bottom dishes (MatTek) and transfected with enhanced excitation-ratiometric PKA biosensor pcDNA3.1(+)-ExRai-AKAR2 (for global PKA) or pcDNA3-mitoExRai-AKAR2 (for mitochondrial PKA) 27
, Buckley, S
Mast cell stabilizer (MCAS Connection): GLP-1 receptors are also found on mast cells, and recent studies have shown that GLP-1 RA drugs prevent overactive mast cell degranulation
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