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It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus

It requires prescribers to extend the treatment conversation beyond the pharmacology

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Efficacy Evidence in Older Adult Populations A subset analysis from the SUSTAIN trials (semaglutide for type 2 diabetes) showed adults aged 65+ achieved mean weight reductions of 4-8 kg over 56 weeks on semaglutide 1 mg weekly, with similar relative improvements to younger participants