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HGH is more commonly associated with water retention, insulin resistance , and organ growth at extreme doses

Treatment resistance often stems from either increased anti-death signals or decreased pro-death protein function [34,35,36,37]

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57 In meal tolerance testing, tirzepatide also reduced fasting and mealstimulated glucagon secretion

The potential for protein carbonylation to inactivate key antioxidant enzymes has not been well studied despite the potential relevance to T2D etiology