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Some common symptoms of hypothyroidism include fatigue weight gain trouble tolerating cold joint and muscle pain dry skin or dry, thinning hair heavy or irregular menstrual periods or fertility problems slowed heart rate depression Because hypothyroidism develops slowly, you may not notice symptoms of the disease for months or even years

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Another systematic review and network meta-analysis concluded that PRP was the most effective injectable treatment for knee OA compared to corticosteroids and HA (PMID: 35581332)

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NOS, nitric oxide synthase