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Nat Immunol (2017) 18:48898

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Moving from intermittent to more frequent dosing can be implemented immediately without washout since receptor sensitivity should be preserved under spaced administration

At week 26, LDL-C was reduced by 19.0% (-36.0% to -1.9%, p=.029) in the tirzepatide 15 mg group compared to placebo while it was reduced by 17.8% (-33.7% to -2.0%, p= 0.028) in the dulaglutide 1.5 mg group compared to placebo though differences between the 2 medications were not seen [60]