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Personalization Through Genetic Insights: The PlexusDx Advantage While both semaglutide and Ozempic target the GLP-1 receptor, individual response to the medication depends partly on genetic variations in the GLP1R gene (rs6923761), GIPR rs1800437, and metabolic genes like FTO rs9939609 and MC4R rs17782313

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They divided the patients into a semaglutide-versus-other-glucose-lowering-drugs group (10,213 patients) and a semaglutide-versus-SGLT2 inhibitors group (8,605 patients), then carefully adjusted for clinical differences such as age, comorbidities, and body mass index (BMI) to assess the drug's effect

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