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Sikiric P, Seiwerth S, Rucman R, et al

Freezing can cause protein aggregation in the semaglutide component and may damage the physical structure of the solution, potentially leading to particulate formation or changes in drug concentration

Caution is recommended in patients with a psychotic disorder (e.g., schizophrenia due to insufficient data

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[7] Clinicians should exercise extreme caution in advanced chronic kidney disease or sarcoidosis, tuberculosis, and other granulomatous disorders where extrarenal 1-hydroxylase activity can generate excess calcitriol and precipitate hypercalcaemia even at modest serum 25-hydroxyvitamin D concentrations