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Ipamorelin is a selective growth-hormone-releasing peptide (GHRP) that acts through the ghrelin receptor

Sample size calculations were based on phase 2 trial data, which predicted a treatment difference of 1.0 in the Female Sexual Function Index-desire domain (FSFI-D) score and about 20.43 points in the Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO) item 13, with a total of 450 evaluable patients providing sufficient statistical power to detect significant differences

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It works by targeting the receptors of glucagon-like peptide-1 (GLP-1), a gut hormone involved in regulating your digestion, appetite, and blood sugar levels

Most patients tolerate transitions well, but being prepared for potential nausea or other side effects during the first few weeks helps with adherence