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The main therapeutic approaches target brain microvascular endothelium and the BBB, microvascular function, neuroinflammation, and antiplatelet agents

3.3 Challenges of CPP-mediated nasal drug delivery Although CPP-driven nasal delivery is regarded as a promising tool in facilitating non-injectable delivery of drugs, there are some challenges

TB-500 oral bioavailability unclear Local application Topical or injury-site injection in specific models Combination administration Clinical observations use various routes

Immunoprecipitation techniques were used to detect the interactions between GLP-1R and the PKA/CREB pathway

It has also been suggested to have anti-inflammatory properties