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Further, we validated these findings by inhibiting the cellular antioxidant system of the cells in vitro and in vivo in the presence of MTX

Reconstituted solutions should be stored at 28C and used within 30 days

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This hypermetabolic state can initially lead to unintended weight loss, but once treated with antithyroid drugs, beta-blockers, or radioactive iodine, many patients experience weight gain as thyroid levels normalize