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On October 5, 2023, an important study, published in JAMA and authored by Mohit Sodhi, indicated an increased risk of gastroparesis, bowel obstruction, and pancreatitis for those using GLP-1 agonists

"We can't say that GLP-1s are actually causing these symptoms," says Neil Sehgal, the study's first author and a doctoral student in CIS advised by Guntuku and Ungar

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The trial product (primary) estimand evaluated the treatment effect for all randomised participants under the assumption that all participants continued taking the trial product for the entire planned duration of the trial and did not use rescue medication