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Collectively, this representation of coagulant and complement proteins could embody the development of an enhanced thrombotic environment that has been observed with long-term diabetes [42]

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With the development of targeted drugs and combination therapy strategies, preclinical studies and clinical trials on the targeted intervention of Wnt/-catenin signal transduction in malignant tumours have been gradually performed and are promising candidates for individualized therapy in cancer patients

However, significant translational barriers remain: no human pharmacokinetic data, high synthesis cost, unknown long-term safety, and the absence of clinical trials

"I kept asking, which one actually works?" she said