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Gastrointestinal Issues : Mild nausea or upset stomach may occur in some patients, especially if glutathione is administered too rapidly

A Phase II Trial of Azacitidine with Ipilimumab, Nivolumab, or Ipilimumab and Nivolumab with or without Azacitidine in Relapsed or Refractory Myelodysplastic Syndrome

doi: 10.1016/j.freeradbiomed.2005.02.026

Another concern in employing CRISPR/Cas9 in clinical trials is low efficiency due to low specificity and the safety of delivery into cells (469)

ROS derived from NOX family enzymes are inherently dependent on NADPH produced by G6PD while mitochondrial ROS, for example, are largely NADPH-independent