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Signs You Have Hyperthyroidism Hot flushes, sweating Unintentional weight loss Frequent stools, loose stool or diarrhea Difficulty sleeping and insomnia Anxiety, irritability, or constant fatigue Elevated heart rate Changes in menstrual cycles Reduced libido Bulging eyes Thick red skin on shins or feet Increased appetite Osteoporosis Hand tremors Muscle weakness How is Hyperthyroidism Diagnosed