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Of these substrates, cysteine availability is rate-limiting, rendering glutathione synthesis particularly sensitive to dietary protein quality, sulfur amino acid intake, and intracellular redox demand

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By influencing not just inflammation and oxidation but also immune function, neuronal signaling, epithelial regeneration, and microbial ecosystems, plant-derived compounds serve as holistic and promising therapeutic agents in the treatment of GI disorders

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Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)