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The itaconylation of KEAP1 allows NRF2 to activate genes whose encoded proteins serve antioxidant functions

This remarkable 15-amino acid sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) has demonstrated extraordinary healing and protective properties across multiple tissue types and organ systems in extensive preclinical research

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These concerns are based on biological plausibility rather than demonstrated human harm

Despite these advances, important questions remain regarding the long-term durability of benefits, the degree of kidney protection independent of glycemic and weight effects, and the optimal integration of these therapies into routine care