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Doukas J, Blease K, Craig D, Ma C, Chandler LA, Sosnowski BA, Pierce GF: Delivery of FGF genes to wound repair cells enhances arteriogenesis and myogenesis in skeletal muscle

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Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials