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NNMT inhibition may prevent supplement-induced NAD+ turnover-induced methylation depletion by sparing methylation

An unrelated peptide without a human protein correlate previously isolated from HLA-C*06:02 of lymphoblastoid B cells ( Measurement of stimulation-induced [ 3 H]-thymidine incorporation of PBMC and induction of CD137 expression on CD8 + T cells To measure stimulation-induced proliferation, triplicates of PBMC cells were pulsed overnight on day 5 of stimulation with 24,500 bq/well [ 3 H]-thymidine (Hartmann Analytic (Braunschweig, Germany), and proliferation was assessed according to the incorporated radioactivity

The bulk of this evidence is pre-clinical

BMC Cancer 22:635

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