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Sleep deprivation, in the laboratory or due to travel causing jet lag, causes two alterations in the GH secretory pattern: the magnitude of secretory spikes is augmented: the return to pre-travel levels takes at least 11 days and is slower to recover after westward travel

doi: 10.1016/j.cmet.2015.09.025

It reduces peripheral insulin sensitivity by interfering with insulin receptor signaling, promoting hepatic gluconeogenesis, and increasing free fatty acid levels

While both are derived from proglucagon, GLP-1 is primarily used to study insulin secretion and appetite, whereas GLP-2 is used to study intestinal growth and repair