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3) is another TLR family member upregulated in MASLD and lipopolysaccharide (LPS), ROS, HMGB1 and various damage-associated molecular patterns can bind to TLR4 in KCs to promote TNF-, IL-1, IL-6 and interferon- (IFN-) production of various pro-inflammatory cytokines, thereby contributing to hepatic inflammation and the progression of MASLD (54)