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Within development of primary follicle, the granulosa cell communicates with the oocyte through channels made up of connexin proteins, causing dispersion of metabolites, ions, and other compounds, and has a direct effect on the process of folliculation, ovulation, and fertility [5,6,7]

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1H-NMR and HPLC-MS/MS-based global/targeted metabolomic evaluation of Hypericum perforatum L

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