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In summary, this real-world comparative effectiveness study found that adults without diabetes initiating tirzepatide for obesity management achieved greater weight reduction and improvements in select cardiometabolic risk parameters at 6 months than those initiating semaglutide

Visceral fat, which surrounds internal organs, has metabolic properties distinct from those of subcutaneous fat, and excess visceral fat increases the risk of metabolic diseases [179]

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A priori inclusion criteria and duplicate screening decreased the risk of bias

Mitochondrial pathology and glycolytic shift during proximal tubule atrophy after ischemic AKI