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Meta-analysis integrated with multi-omics data analysis to elucidate pathogenic mechanisms of age-related knee osteoarthritis in mice

In contrast, CHAC1-driven GSH degradation reduces protein SSG, enhances transferrin receptor (TFRC)mediated iron uptake, and exacerbates ferroptosis, whereas hemoglobin SSG shields reactive cysteine residues from excessive oxidation 127,128

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In terms of therapeutic potential and clinical relevance, MSC-Exos are ideal for therapeutic use due to their consistent anti-ferroptotic and regenerative properties

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