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doi: 10.1016/S0140-6736(23)02750-2 Wing RR, Phelan S

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A degradation of extracellular ATP to adenosine diphosphate (ADP) is mediated enzymatically by ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) in type I cells, which in turn increases the response to sweet stimuli by binding of ADP to adenosine 2B (A2B) receptors in type II cells [39]

If drawing becomes difficult after multiple doses (typically after 810 draws), you can inject a small volume of sterile air equal to the total volume you've removed so far, but this should be a single event, not a per-dose habit

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