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Availability of data and materials The sequence read data of gut microbiome for characterizing TMAO producers (BioProject:PRJNA589723) were all available on NCBI sequence read archive (SRA) database (SRA accession numbers:SRR10465787-SRR10466048)

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Tirzepatide (Eli Lilly, 2022) redrew the map with dual GLP-1/GIP mechanism