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Early trials in men showed that PT-141 produced penile erections in the absence of external stimulation a finding with significant mechanistic implications, as it demonstrated central-pathway arousal independent of peripheral vascular action

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Second, the C677T and A1298C variants are very common: in some ethnicities, more than 50 percent of people have at least one copy of one of these variants

Buckley ST, Bkdal TA, Vegge A et al (2018) Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist