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The realized revenues and projected growth from this portfolio of AOMs is expected to make this line of medicines the bestselling medicine in history according to a recent Wall Street Journal article

However, through the $10 billion acquisition of clinical-stage biotech company Metsera in November 2025, Pfizer secured a next-generation obesity pipeline after an aggressive bidding war with Novo

Larger prospective studies are needed to better define the role of GLP-1 RAs in this underrepresented population

This is likely a result of the inherent complexity in investigating the potential interplay between nutritional factors, microbial composition, genome and epigenome and its impact on female reproduction (77)