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While off-label prescribing is a common practice and one allowed by the FDA the deliberate promotion of drugs for unapproved uses can be construed as prioritizing market expansion over patient welfare

Overlapping side effects to monitor Some side effects overlap between HRT and GLP-1 medications, which can make it difficult to identify which medication is causing a particular symptom

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The efficacy of subcutaneous semaglutide was established in the phase III SUSTAIN program (SUSTAIN 15 and 7), in which significant reductions in mean glycated hemoglobin (HbA 1c ) and body weight were demonstrated against placebo and a variety of active comparators in multiple patient groups with T2D [26,27,28,29,30,31,32,33]