Lastly, the interplay between Nf-B and Nrf2 pathways significantly influences the progression of long-term COVID neuropsychiatric complications [200-202], and astrocyte-neuron communication via the astroglial xc-system is crucial for synaptic glutamatergic regulation [203]
Several studies employing single-cell RNA sequencing, mass cytometry, and fluorescence cytometry revealed phenotypic alterations in microglia across various models, although spatial information was limitedly obtained and the pathological mechanisms remained unclear at that time
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In other words, without VIP, the lungs default to an asthmatic, allergic state