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Exendin-4 (10 g/kg) treated SD rats by subcutaneous injection for 75 days, reduced body weight by approximately 30%, significantly reduced insulin, adiponectin, and leptin levels, but caused pancreatic acinar inflammation and pus toxicosis [7]

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And since the weight loss did not plateau at the study cutoff, even greater results are possible with extended treatment

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[DOI] [PubMed] [Google Scholar] Pasternak M, Lim B, Wirtz M, Hell R, Cobbett CS, Meyer AJ