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Because cysteine availability often constrains the first enzymatic step (catalyzed by gamma-glutamylcysteine synthetase), NAC supplementation bypasses the bioavailability problem of oral glutathione and supports endogenous GSH production

Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor

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Study eligibility criteria We included randomized controlled trials (RCTs), cohort studies, casecontrol studies, cross-section studies, and case series studies that evaluated the impact of L-carnitine on children