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73 There exists an alternative model of GLP-1R activation in which it is proposed that binding of GLP-1(736)amide to the receptor results in a structural rearrangement of the receptor's N-terminal domain so that a pentapeptide NRTFD signature sequence within the N-terminus of the receptor acts as an endogenous agonist at ECL-2 or ECL-3 of the receptor

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Disclosure of interest: Sheng-Feng Sung: This research was supported by the National Science and Technology Council [grant number NSTC 112-2221-E-705-001-MY2]

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