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90 An ad hoc analysis revealed increased use of antiarrhythmic drugs and worse outcomes in patients with NYHA class IIIIV symptoms and diabetes
For example, splicing at SS2 in neurexins modulates binding to dystroglycans, and splicing regulation at SS4 alters the affinity of neurexins for postsynaptic adhesion molecules such as neuroligins, dystroglycans, LRRTMs, calsyntenins, and latrophilins [72, 77, 79]
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Early Clinical Evidence (Small but Promising) A 2025 case series followed five women with lipedema and insulin resistance treated with the GLP-1 medication exenatide (Patton et al., 2025)