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This is a common question for people prescribed glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes or obesity

These include new or worsening depression, persistent feelings of hopelessness, thoughts of self-harm or suicide, severe anxiety or panic attacks, unusual irritability or agitation, and significant sleep disturbances

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Post-marketing surveillance and clinical data suggest the risk remains low, though individuals with a personal or family history of pancreatitis face elevated concern