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Clinical pharmacokinetics, 2003, 42(11): 941-967

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AMPs Combined with Chemotherapy Drugs for Cancer Treatment In 1992, Ohsaki et al 146 discovered for the first time that the antimicrobial peptide Magainin analogs combined with chemotherapy drugs such as adriamycin and cisplatin showed an additive inhibitory effect on tumor cells

The presence of three chiral centers in the saturated side chain, presenting as either R- or S-configuration, leads to eight different stereoisomers, among which only -tocopherol in its RRR conformation is selectively retained and incorporated into lipoproteins, while non--tocopherol congeners are preferentially metabolized and excreted (Podszun and Frank 2021)

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