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Some patients report that waiting 2-3 minutes before resuming normal activity allows initial pH normalization

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Therefore, it is of critical importance that the extracellular glutamate concentration must be kept enough low due to the toxicity of glutamate in high concentrations

A multicentre retrospective study of 499 patients identified ICI patients with renal cell carcinoma (RCC) in which 80 patients developed severe irAEs warranting treatment cessation, 36 of whom were able to be restarted on an ICI agent and 44 permanently discontinued