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In contrast, the concentration of copper in the synaptic cleft has been claimed to range from 1 to 10 M, as determined by using the fluorescent indicator tetrakis-(4-sulfophenyl)-porphine (TSPP) in bovine chromaffin cells [250]

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A 2026 study (PMID 41418663) used IGF-1 LR3 as the therapeutic agent in a rat volumetric muscle loss (VML) model, delivering the peptide via poly(lactic-co-glycolic acid) microencapsulation within a polyethylene glycol-acrylate hydrogel void filler