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HO-1, an important source of intracellular iron, plays a key role in ferroptosis induced by erastin (67)

Since copper on its own can do things, and you need to know whether an effect came from the intact peptide-copper complex or just from free copper ions

3.6 Determination of urine TMA levels in C57Bl/6-Fmo3 em1smoc mice TMA levels were evaluated in urine collected from C57Bl/6-Fmo3 em1smoc mice, which lack the Fmo3 enzyme responsible for the conversion of TMA to TMAO

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These symptoms develop gradually because the body stores several years worth of B12 in the liver, meaning deficiency takes time to become clinically apparent