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Standard practice is 12mL

In many cases, several factors need to be addressed

Analyzing a series of studies using differing amounts of B12 via injection, the IOM determined that 1.5 g of absorbed B12 per day was enough to normalize red blood cell parameters (hematocrit, red blood cell volume, and anemia) in the average patient with pernicious anemia

People who suffer from depression also may be found to be deficient in Vitamin B12 in their system

Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I et al (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomized, non-inferiority clinical trial (OB12)