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Among these, thymosin beta-4 (TB-4) and its shorter synthetic fragment TB-500 are increasingly central to regenerative biology research
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On the other hand, the activation of astrocytes by the increase of proinflammatory cytokines causes an increase of intracellular ROS that decreases the expression of glutamate transporters and increases their release, thus increasing the levels of extracellular glutamate and generating more neurotoxicity by a greater activation of NMDA receptors (199)
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