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GLP-1 also slows down stomach emptying and increases the sense of fullness after eating

The combination may reduce gut inflammation on multiple levels, including systemically, via cytokine signaling, and through modulation of the intestinal immune response

PloS One, 10(4), e0125879

"You might lose a good amount of weight right away, but your metabolism quickly goes into survival mode." The change in the metabolism is a key reason why people regain weight after dieting