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While the results in AD models are mixed, with benefits varying between specific models, GLP-1RAs show consistent neuroprotective effects in PD models, protecting dopaminergic neurons and reducing inflammation

Methods This is a retrospective cohort analysis of approximately two million people with type 2 diabetes receiving insulin across 97 healthcare organisations using a global federated health research network (TriNetX, Cambridge, USA)

What rarely gets discussed: longer gaps between injections (a week or more) can trigger a partial reset of receptor sensitivity